Publications & Reports
Call for Abstracts: 8th International UHMWPE Meeting in Torino, Italy
The University of Torino, the Implant Research Center of Drexel University and Exponent, Inc., are pleased to announce a call for abstracts for the 8th International UHMWPE Meeting, which will be convened in Torino, Italy, on Thursday and Friday, October 19 and 20, 2017. The purpose of the meeting is to bring together engineers, scientists, and clinicians from academia and industry and present leading edge research on advancements in medical grade UHMWPE technology and clinical applications.
Final Program and Conference Proceedings: 7th International UHMWPE Meeting in Philadelphia
The Implant Research Center of Drexel University and Exponent, Inc., have archived the final program and conference proceedings for the 7th International UHMWPE Meeting, which was convened at the Union League, Philadelphia PA, USA, on Thursday and Friday, October 22 and 23, 2015. The purpose of the meeting was to bring together engineers, scientists, and clinicians from academia and industry and present leading edge research on advancements in medical grade UHMWPE technology and clinical applications. The focus of the 7th meeting was on clinical and retrieval studies of highly crosslinked UHMWPE (HXLPE); novel UHMWPE articulations with ceramic and PEEK bearing surfaces; advances in thermal processing and new antioxidant technologies for UHMWPE; astructural composites and woven fiber applications of medical grade UHMWPE; as well as advances in biologic aspects of UHMWPE wear debris.
Draft FDA Guidance for Characterization of UHMWPE
FDA has developed this draft guidance document for members of industry who submit and FDA staff who review testing of orthopedic devices using ultrahigh molecular weight polyethylene (UHMWPE) material. This guidance addresses the characterization and testing of orthopedic devices that use UHMWPE materials such as conventional UHMWPE, highly crosslinked UHMWPE, and highly crosslinked UHMWPE containing vitamin E. This document outlines the information that the FDA recommends should be included in a submission to FDA to characterize the UHMWPE material (e.g., material description, sterility, biocompatibility, mechanical properties, and chemical properties).
PhD Disseration: Biologic Response to Wear Debris in Total Disc Replacement
In this PhD Dissertation, Sai Veruva investigated both explants and periprosthetic tissue retrievals from patients with gamma-inert-sterilized TDRs to characterize in vivo performance and biological response, respectively. As pain was the primary revision reason for all patients, the contributions of implant-related damage and tissue responses to the development of pain were also a focus of this investigation.
Retrieval Analysis of Sequentially Annealed HXLPE in THA
First-generation annealed and second-generation sequentially annealed, highly crosslinked polyethylenes (HXLPEs) have documented reduced clinical wear rates in their first decade of clinical use compared with conventional gamma inert-sterilized polyethylene. This retrieval study examines their reasons for revision, their in vivo oxidative stability, and their resistance to mechanical degradation. Researchers observed evidence of in vivo oxidation in retrieved annealed and, to a lesser extent, retrieved sequentially annealed acetabular liners.
Editorial: Arthroplasty devices: Registries and beyond.
Established international registries such as those implemented in Australia, as well as in England and Wales, effectively monitor both the successes and the problems associated with newly introduced implants. Similarly, the establishment of the International Consortium of Orthopedic Registries, consisting of 29 international registries with information covering more than 3.6 million orthopaedic implants, represents an unprecedented effort to collate this information into an even more effective resource. This editorial, co-authored by the FDA, explains the US clinical and regulatory need, as well as an unprecedented opportunity, for further development of national and international initiatives aimed at capturing and synthesizing interdisciplinary (clinical, biological, technological) evidence for more comprehensive analysis of the causes pertaining to orthopaedic revision burden.
Editorial Comment from CORR Symposium: Advances in UHMWPE Biomaterials
Ten papers that were presented at the 6th International UHMWPE Meeting, which took place in Torino, Italy, from October 10-11, 2013, have now been published as a CORR Symposium: Advances in UHMWPE Biomaterials. The editorial comment for this issue is also made available here on the UHMWPE Lexicon website. CORR has agreed to produce another UHMWPE Symposium for the proceedings of the 7th International UHMWPE Meeting, that will be held in Philadelphia, PA, USA, from October 22-23, 2015.
Noteworthy in 2014: What Are the Current Clinical Issues in Wear and Tribocorrosion?
This review paper provides an overview of the wear and corrosion problems facing contemporary total joint arthroplasty from a clinicians perspective. The paper was presented during a three-day Carl T. Brighton Worshop on Implant Wear and Tribocorrosion, convened by the Association of Bone and Joint Surgeons on November 21-23, 2013 in Tampa Bay, Florida. In particular, this review illustrates the extent to which polyethylene wear is no longer on a pedestal by itself, but has been eclipsed by problems associated with alternative bearings and metal release from modular connections. Click here to see a brief commentary by the Editor of the UHMWPE Lexicon.
Super CTPOD Wear Studies of Retrieved UHMWPE Components
Researchers from Drexel University have assessed the suitability of using multi-directional pin-on-disk (POD) testing to characterize the wear behavior of retrieved ultra-high molecular weight polyethylene (UHMWPE). The results of this study support the utility of using modern, multidirectional POD testing with a physiologic lubricant as a novel method for evaluating the in vivo wear properties of retrieved UHMWPE components.
Conference Proceedings and Abstracts: 6th International UHMWPE Meeting, Torino Italy
The University of Torino in collaboration with the Implant Research Center of Drexel University and Exponent organized the 6th International UHMWPE Meeting, which was convened at the Congress Center "Unione Industriale," in Torino Italy, on Thursday and Friday, October 10-11, 2013. The purpose of the meeting was to bring together engineers, scientists, and clinicians from academia and industry and present leading edge research on advancements in medical grade UHMWPE technology and clinical applications. The abstracts and final agenda for the meeting are now available for download. Check back soon for PDFs of the individual presentations and posters, which will be uploaded to the website with the authors' permission.