The UHMWPE Lexicon is the online reference for ultra-high molecular weight polyethylene used in total joint replacements. The additional goals for this website are to provide an overview of state-of-the-art research in several key polyethylene related problems of clinical significance and to encourage hypothesis driven polyethylene research. [+] Read more about us.

Publications & Reports

Final Program and Conference Proceedings: 7th International UHMWPE Meeting in Philadelphia

The Implant Research Center of Drexel University and Exponent, Inc., have archived the final program and conference proceedings for the 7th International UHMWPE Meeting, which was convened at the Union League, Philadelphia PA, USA, on Thursday and Friday, October 22 and 23, 2015. The purpose of the meeting was to bring together engineers, scientists, and clinicians from academia and industry and present leading edge research on advancements in medical grade UHMWPE technology and clinical applications. The focus of the 7th meeting was on clinical and retrieval studies of highly crosslinked UHMWPE (HXLPE); novel UHMWPE articulations with ceramic and PEEK bearing surfaces; advances in thermal processing and new antioxidant technologies for UHMWPE; astructural composites and woven fiber applications of medical grade UHMWPE; as well as advances in biologic aspects of UHMWPE wear debris.

Draft FDA Guidance for Characterization of UHMWPE

FDA has developed this draft guidance document for members of industry who submit and FDA staff who review testing of orthopedic devices using ultrahigh molecular weight polyethylene (UHMWPE) material. This guidance addresses the characterization and testing of orthopedic devices that use UHMWPE materials such as conventional UHMWPE, highly crosslinked UHMWPE, and highly crosslinked UHMWPE containing vitamin E. This document outlines the information that the FDA recommends should be included in a submission to FDA to characterize the UHMWPE material (e.g., material description, sterility, biocompatibility, mechanical properties, and chemical properties).

PhD Disseration: Biologic Response to Wear Debris in Total Disc Replacement

In this PhD Dissertation, Sai Veruva investigated both explants and periprosthetic tissue retrievals from patients with gamma-inert-sterilized TDRs to characterize in vivo performance and biological response, respectively. As pain was the primary revision reason for all patients, the contributions of implant-related damage and tissue responses to the development of pain were also a focus of this investigation.

The 3rd Edition of the UHMWPE Biomaterials Handbook

The 3rd Edition of the UHMWPE Biomaterials Handbook, edited by Steven M. Kurtz, Ph.D., is published by Elsevier Academic Press. Now with 41 chapters, the third edition includes six new chapters on a range of topics, including the latest in anti-oxidant technologies for stabilizing HXLPE and up-to-date systematic reviews of the clinical literature for HXLPE in hips and knees. The book chronicles the rise and fall of all-metal hip implants, as well as the increased use of ceramic biomaterials and UHMWPE for this application. This book also brings orthopedic researchers and practitioners up to date on the stabilization of UHMWPE with antioxidants, as well as the choices of antioxidant available for practitioners. The book can be ordered via the Amazon website or downloaded as an Ebook. A preview of the Ebook is also available.

Conferences Updates

Announcing the 8th International UHMWPE Meeting in Torino, Italy

We are pleased to announce that the 8th UHMWPE International Meeting will be convened in Torino, Italy, in October 2017. The meeting is being organized by the University of Torino in collaboration with the Implant Research Center of Drexel University and Exponent. Check back soon for more details about the conference. 

Standards Updates

UHMWPE Standards at ASTM

The Working Group for UHMWPE convenes twice per year at the ASTM F04 Committee Week meetings in May and November. Check the ASTM Website for more details on the F04 Committee Week.